endothelial cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2195	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell		Others
	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the pro...		Others
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T25340	Diprotin A	Ile-Pro-Ile	DPP-4
	Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.		DPP-4
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T6351	MGCD-265 analog	MGCD-265,Glesatinib	Apoptosis , VEGFR , c-Met/HGFR
	MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.		Apoptosis , VEGFR , c-Met/HGFR
T2456	Tivozanib	AV-951,KRN951	VEGFR , PDGFR , Ephrin Receptor
	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.		VEGFR , PDGFR , Ephrin Receptor
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T3567	SU 4942		Others
	SU-4942 is a modulator of tyrosine kinase signaling. SU-4942 has inhibitory effects on endothelial cell mitosis induced by VEGF and endothelial cell growth factor (ECGF).		Others
T63918	α-Tocopherol phosphate disodium	TocP disodium,Vitamin E phosphate disodium	Apoptosis , Antioxidant , Reactive Oxygen Species
	α-Tocopherol phosphate (alpha-Tocopherol phosphate) is an antioxidant that scavenges UVA1-induced reactive oxygen species (ROS) and protects against long-wave UVA1-induced cell death. alpha-Tocopherol phosphate disodium ...		Apoptosis , Antioxidant , Reactive Oxygen Species
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T2064	Semaxinib	SU5416	VEGFR
	Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the...		VEGFR
T60396	JMS-053		Phosphatase
	JMS-053 is a potent and selective inhibitor of the phosphatase DUSP3, inhibits PTP4A3, PTP4A1, PTP4A2 and CDC25B, inhibits cancer cell migration and sphere growth, and avoids disruption of the microvascular endothelial b...		Phosphatase
TN1421	Bacopaside II		Apoptosis
	Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.		Apoptosis
T7486	Imeglimin hydrochloride	EMD 387008 hydrochloride	Reactive Oxygen Species , Mitochondrial Metabolism
	Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.		Reactive Oxygen Species , Mitochondrial Metabolism
T2576	Brivanib (alaninate)	BMS-582664,Brivanib Alaninate	VEGFR , FGFR , Autophagy
	Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosi...		VEGFR , FGFR , Autophagy
T67708	Thiolutin	Acetopyrrothin	Antibacterial , Antibiotic
	Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.		Antibacterial , Antibiotic